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Allopurinol

dm+d VMPP - 1189011000001101

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Allopurinol, sold under the brand name Zyloprim among others, is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It is taken by mouth or injected into a vein.Common side effects when used by mouth include itchiness and rash. Common side effects when used by injection include vomiting and kidney problems. While not recommended historically, starting allopurinol during an attack of gout appears to be safe. In those already on the medication, it should be continued even during an acute gout attack. While use during pregnancy does not appear to result in harm, this use has not been well studied. Allopurinol is in the xanthine oxidase inhibitor family of medications.Allopurinol was approved for medical use in the United States in 1966. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Allopurinol is available as a generic medication. The wholesale cost in the developing world is about US$0.81–3.42 per month. In the United States a month of treatment costs less than $25. In 2016 it was the 52nd most prescribed medication in the United States with more than 15 million prescriptions.

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