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Lamotrigine

dm+d VMPP - 3144911000001100

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Lamotrigine, sold as the brand name Lamictal among others, is an anticonvulsant medication used to treat epilepsy and bipolar disorder. For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome. In bipolar disorder, it is used to treat acute episodes of depression and rapid cycling in bipolar type II and to prevent recurrence in bipolar type I.Common side effects include sleepiness, headache, vomiting, trouble with coordination, and rash. Serious side effects include lack of red blood cells, increased risk of suicide, Stevens-Johnson syndrome, and allergic reactions. Concerns exist that use during pregnancy or breastfeeding may result in harm. Lamotrigine is a phenyltriazine, making it chemically different from other anticonvulsants. How it works is not exactly clear. It appears to increase the action of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system and decrease voltage-sensitive sodium channels.Lamotrigine was first marketed in the United Kingdom in 1991 and approved for use in the United States in 1994. It is on the World Health Organization's List of Essential Medicines, the most effective and safest medicines needed in a health system. The wholesale cost in the developing world is about 3.57 USD per month as of 2015. In the United States, this amount has a wholesale cost of about 4.64 USD.

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