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Levothyroxine

dm+d VMPP - 1199511000001105

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Levothyroxine, also known as L-thyroxine, is a manufactured form of the thyroid hormone thyroxine (T4). It is used to treat thyroid hormone deficiency, including the severe form known as myxedema coma. It may also be used to treat and prevent certain types of thyroid tumors. It is not indicated for weight loss. Levothyroxine is taken by mouth or given by injection into a vein. Maximum effect from a specific dose can take up to six weeks to occur.Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, tremor, and fast heart rate. Use is not recommended in people who have had a recent heart attack. Use during pregnancy has been found to be safe. It is recommended that dosing be based on regular measurements of thyroid-stimulating hormone (TSH) and T4 levels in the blood. Much of the effect of levothyroxine is following its conversion to triiodothyronine (T3).Levothyroxine was first made in 1927. It is on the World Health Organization's List of Essential Medicines, which lists the most effective and safe medicines needed in a health system. Levothyroxine is available as a generic medication. The wholesale cost in the developing world is about US$0.58 to US$12.28 per month. In the United States, a typical month of treatment costs less than US$25. Levothyroxine was the most commonly prescribed medication in the United States as of 2016, with more than 114 million prescriptions.

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