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Loperamide

dm+d VMPP - 986911000001109

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Loperamide, sold under the brand name Imodium, among others, is a medication used to decrease the frequency of diarrhea. It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome. It is not recommended for those with blood in the stool. The medication is taken by mouth.Common side effects include abdominal pain, constipation, sleepiness, vomiting, and a dry mouth. It may increase the risk of toxic megacolon. Loperamide's safety in pregnancy is unclear, but no evidence of harm has been found. It appears to be safe in breastfeeding. It is an opioid with no significant absorption from the gut and does not cross the blood–brain barrier when used at normal doses. It works by slowing the contractions of the intestines.Loperamide was first made in 1969 and used medically in 1976. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Loperamide is available as an inexpensive generic medication. The wholesale cost in the developing world is about US$0.004 to 0.040 per dose. In August 2016, the US retail cost is about US$0.31 per dose. In 2016, it was the 256th-most prescribed medication in the United States with more than a million prescriptions.

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