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Nifedipine

dm+d VMPP - 1097411000001108

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Drug Description

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Nifedipine, sold under the brand name Adalat among others, is a medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother to a well qualified medical facility before delivery. Nifedipine is taken by mouth and comes in fast and slow release formulations.Common side effects include lightheadedness, headache, feeling tired, leg swelling, cough, and shortness of breath. Serious side effects may include low blood pressure and heart failure. There is tentative evidence that its use in pregnancy is safe; however, it is not recommended during breastfeeding. It is a calcium channel blocker of the dihydropyridine type.Nifedipine was patented in 1967 and approved for use in the United States in 1981. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale price in the developing world for the slow-release form is approximately US$1.90–3.80 per month. In the United States, it costs approximately $40–60 per month, depending on the dose. In 2016 it was the 154th most prescribed medication in the United States with more than 4 million prescriptions.

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