dm+d VMPP - 1117511000001104
Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.Common side effects include constipation, headaches, and nausea. Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. A lower dose may be needed in people with kidney problems. There is evidence of harm to the developing baby when taken during pregnancy and it should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.Simvastatin patented by Merck in 1980 and came into medical use in 1992. It is on the World Health Organization's List of Essential Medicines, which lists the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is US$0.01 to 0.12 per day as of 2014. In the United States, it costs between US$0.50 and 1.00 per day. Simvastatin is made from the fungus Aspergillus terreus. In 2016, it was the 8th most prescribed medication in the United States, with more than 65 million prescriptions.
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