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Sulfasalazine

dm+d VMPP - 1146811000001108

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Drug Description

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Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first line treatment in rheumatoid arthritis. It is taken by mouth.Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Severe side effects include bone marrow suppression, liver problems, and kidney problems. It should not be used in people allergic to aspirin or sulfonamide. Use during pregnancy appears to be safe for the baby. Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works but is broken down into sulfapyridine and 5-aminosalicylic acid.Sulfasalazine was approved for medical use in the United States in 1950. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Sulfasalazine is available as a generic medication. The wholesale cost in the developing world is about US$9–33 a month. In the United States it costs $25–50 per month.

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