dm+d VMPP - 1205011000001104
Tibolone, sold under the brand names Livial and Tibofem among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken by mouth.Side effects of tibolone include acne and increased hair growth among others. Tibolone is a synthetic steroid with weak estrogenic, progestogenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptors. It is a prodrug of several metabolites. The estrogenic effects of tibolone are selective to certain tissues, with such effects in bone, the vagina, and the brain, but not in the uterus, breast, or liver.Tibolone was developed in the 1960s and was introduced for medical use in 1988. It is marketed widely throughout the world, for instance in Europe. The medication is notably not available in the United States or Canada. It is a controlled substance in Canada, with the classification of an anabolic steroid.
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